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KMID : 0370220100540060461
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Yakhak Hoeji
2010 Volume.54 No. 6 p.461 ~ p.465
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The Regulation of Osteoclastogenesis by L-Type Channel Agonist
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Noh A Long Sae Mi
Yim Mi-Jung
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Abstract
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We investigated the role of L-type channel in receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation. BayK 8644, a L-type channel agonist, was shown to increase the RANKLinduced osteoclastogenesis and actin ring formation in mouse bone marrow-dereived macrophage (BMM) culture system. BayK 8644 stimulated RANKL-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation, which leads to increased nuclear factor of activated T cells (NFAT)c1 expression. Taken together, these data indicate that L-type channel regulates osteoclast formation possibly through ERK- and p38-mediated NFATc1 expression.
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KEYWORD
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L-type channel, osteoclast, NFATc1, ERK, p38
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